Naftidrofuryl for Intermittent Claudication, a Meta Analysis
(2006) 22nd International conference on Pharmacoepidemiology and therapeutic Risk Management, August 24-27 — Location: Lisbon , Portugal
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- Authors
Lehert, Philippe 
- Abstract
- (en) Objectives: Assessing the efficacy of a pharmaceutical agent throughout an Individual Patient Data Meta-analysis IPD-MA. Of 7 available studies, 6 were considered as acceptable, for a total of 1266 randomized patients. We were able to match all the Previous results of original publications. The geometric mean ratio of CD improvement naftidrofuryl/placebo was 1.41 (95%CI 1.32-1.51, p<0.001), and the Number Needed to Treat 5, with results robust to sensitivity analysis. The difficulties and potential of bias of performing IPD in the pharmaceutical sector will be discussed. The implications of the evidence that naftidrofuryl has a clinically meaningful effect in improvement of claudication distance will be discussed in the light of subjective outcomes and hard endpoints.
- Affiliations
Louvain School of Management
Citations
Vander Stichelen, R., VanBortel, L., Lehert, P., & Debacker, T. (2006). Naftidrofuryl for Intermittent Claudication, a Meta Analysis. 22nd International conference on Pharmacoepidemiology and therapeutic Risk Management, August 24-27, Lisbon , Portugal. https://hdl.handle.net/2078.5/128949