Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin.
(2005) Diabetic Medicine: journal of diabetes UK — Vol. 22 (2005)
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- Authors
- Abstract
- (en) We investigated in a double-blind study whether metformin reduces blood pressure (BP) in patients with Type 2 diabetes intensively treated with insulin. 220 patients with Type 2 diabetes were asked to undergo 24-h ambulatory BP monitoring (24-h ABPM). Systolic BP (SBP), diastolic BP (DBP), pulse BP (PP), mean BP (MP) and heart rate (HR) were measured as office BP measurements and as 24-h ABPM for 24-h, day and night. Office BP measurements did not differ significantly between the placebo- and metformin-treated groups for any BP measure, but showed a non-significant trend for SBP reduction with metformin use (mean baseline-adjusted difference, metformin minus placebo: -4.2 mmHg, 95% CI, -9.9 to +1.5; P = 0.15).Conclusion: Metformin does not significantly affect BP in patients with Type 2 diabetes intensively treated with insulin
- Affiliations
Louvain School of Management
Citations
Wulffele, M. G., Stehouwer, C., Donker, A., Bets, D., Lehert, P., & Kooy, A. (2005). Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin. Diabetic Medicine: journal of diabetes UK, 22. https://hdl.handle.net/2078.5/128539 (Original work published 2005)