Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury.

Arrault, Axelle;Dubuisson, Marlène;Gharbi, Sonia;Marchand, Cécile;Marchand-Brynaert, Jacqueline;et.al.
(2003) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 13, n° 4, p. 653-656 (2003)

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Abstract
A series of 2-substituted 3,7-dihydroimidazolo[1,2-a]pyrazine-3-ones has been synthesized and evaluated for their antioxidant activity. Compounds 1-8 are inhibitors of AAPH-induced lipid peroxidation (in vitro) and excellent protectors against microvascular damages in ischemia/reperfusion (in vivo). Hence, the bicyclic structure typical of coelenterazine (luciferin) could be considered as a useful lead in medicinal chemistry.
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Arrault, A., Dubuisson, M., Gharbi, S., Marchand, C., Verbeuren, T., Rupin, A., Cordi, A., Bouskela, E., Rees, J.-F., & Marchand-Brynaert, J. (2003). Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 13(4), 653-656. https://doi.org/10.1016/S0960-894X(02)01049-1 (Original work published 2003)