Dose-effect relationship for in vivo and in vitro induction of dicentric aberrations in blood lymphocytes of children
(1995) Radiation Research : an international journal — Vol. 141, n° 1, p. 95-98 (1995)
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- Abstract
- Chromosome aberrations induced in vivo were studied in nine children 5-12 years old treated with total-body high-energy photon irradiation (pulsed exposure from a LINAC) for different types of malignant diseases. Dose-effect relationships were obtained for each child by taking blood at different times during exposure. In vitro dose-effect relationships for chromosome aberrations in children and adults were obtained by exposing blood under the same conditions as the children. Exposure in vivo and in vitro yielded similar linear-quadratic dose-effect relationships for dicentric aberrations. The response in vitro was slightly greater than in vivo, but the difference was not very large. It is concluded that the dose-effect relationship for dicentric chromosome aberrations obtained in vitro for adults can be used for biological dosimetry in irradiated children. Some of the children displayed a high number of "rogue cells" before exposure; this may be due to the malignant disease as it was not found in the healthy controls.
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Citations
Léonard, A., Baltus, I., Léonard, E. D., Gerber, G. B., Richard, F., & Wambersie, A. (1995). Dose-effect relationship for in vivo and in vitro induction of dicentric aberrations in blood lymphocytes of children. Radiation Research : an international journal, 141(1), 95-98. https://doi.org/10.2307/3579096 (Original work published 1995)