Comparison of thermostable macromolecular antigens from leprosy-associated bacteria.
(1994) Canadian Journal of Microbiology — Vol. 40, n° 6, p. 508-512 (1994)
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- Abstract
- Three types of bacteria are associated with leprosy: Mycobacterium leprae, leprosy-derived corynebacteria (LDC), and armadillo-derived mycobacteria (ADM). The immunological relationships between these three types of bacteria and Mycobacterium bovis BCG, used as a reference, were determined by cross-immunoelectrophoresis. When compared with the reference, cross-reactions were observed with a variable number of antigens: 2 in the case of strain LDC 15, 4 with M. leprae, and from 1 to 10 in the case of the ADM, depending on their subgroup. Next, thermostable macromolecular antigens (TMAs), the major cross-reactive antigens of leprosy-associated bacteria, were compared by anti-TMA antibody ELISA tests. The LDC TMAs displayed high cross-reactivity between the subgroups and lower cross-reactivity with the TMAs of M. bovis BCG. Evidence for the presence of a species-specific moiety in TMA of the different LDC was obtained by using depleted anti-TMA antisera. Western blot analysis revealed the presence of many proteins in the TMAs of LDC and M. bovis BCG, some of them being species-specific and other cross-reactive.
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Baelden, M. C., Bouckaert, A., Grégoire, D., van de Poele, M., & Coene, M. (1994). Comparison of thermostable macromolecular antigens from leprosy-associated bacteria. Canadian Journal of Microbiology, 40(6), 508-512. https://doi.org/10.1139/m94-083 (Original work published 1994)