Lymphocytic choriomeningitis virus-induced alterations of T helper-mediated responses in mice developing autoimmune hemolytic anemia during the course of infection.

El Azami El Idrissi, M;Mazza, G.;Monteyne, P.;Elson, C J;Coutelier, Jean-Paul;et.al.
(1998) Society for Experimental Biology and Medicine. Proceedings — Vol. 218, n° 4, p. 349-356 (1998)

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  • El Azami El Idrissi, M
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  • Mazza, G.
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  • Monteyne, P.
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  • Elson, C J
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  • Coutelier, Jean-Paulorcid-logoUCLouvain
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Abstract
The effect of LCMV on CD4+ T lymphocytes was analyzed in C3HeB/FeJ mice after infection with the Docile strain of this virus. Our results indicated that LCMV triggers: i) an inhibition of Th2 lymphocyte differentiation induced by concomitant immunization with a nonviral protein antigen; ii) a depression of T helper-dependent antibody responses elicited by such an immunization; and iii) a CD4+ cell-mediated proliferation of spleen cells leading to increased interleukin-4 and interferon-gamma message expression and IgG2a-restricted total immunoglobulin secretion. Taken together, these results indicate that LCMV profoundly affects CD4+ cell-mediated immune responses in infected animals. Such modulations of T-helper functions may explain the preponderance of IgG2a in the antierythrocyte autoimmune response induced by the virus in C3HeB/FeJ mice.
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El Azami El Idrissi, M., Mazza, G., Monteyne, P., Elson, C. J., Day, M. J., Pfau, C. J., & Coutelier, J.-P. (1998). Lymphocytic choriomeningitis virus-induced alterations of T helper-mediated responses in mice developing autoimmune hemolytic anemia during the course of infection. Society for Experimental Biology and Medicine. Proceedings, 218(4), 349-356. https://hdl.handle.net/2078.5/135847 (Original work published 1998)