Connective synthesis of spirovetivanes: Total synthesis of (+/-)-agarospirol, (+/-)-hinesol and (+/-)-alpha-vetispirene

Maulide, Nuno;Vanherck, JC.;Marko, Istvan
(2004) European Journal of Organic Chemistry — n° 19, p. 3962-3967 (2004)

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  • Maulide, NunoUCLouvain
    Author
  • Vanherck, JC.
    Author
  • Marko, IstvanUCLouvain
    Author
Abstract
A concise, connective synthesis of naturally occurring spirovetivanes 1 and 3, in racemic form, is presented. This novel approach involves the efficient assembly of the advanced intermediate 12 through a unique spiroannulation protocol.
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Maulide, N., Vanherck, JC., & Marko, I. (2004). Connective synthesis of spirovetivanes: Total synthesis of (+/-)-agarospirol, (+/-)-hinesol and (+/-)-alpha-vetispirene. European Journal of Organic Chemistry, 19, 3962-3967. https://doi.org/10.1002/ejoc.200400236 (Original work published 2004)