Pheochromocytoma during pregnancy: Case report and review of recent literature.
(2017) Annales d’Endocrinologie — Vol. 78, n° 5, p. 480-484 (2017)
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- (en) A 27-year-old woman with a known MEN 2A syndrome due to a C634R ret mutation was seen for routine screening. Total prophylactic thyroidectomy had been performed at the age of 14 for a medullary thyroid cancer (MTC) and her first child was born 3 years before at term by vaginal delivery. Several family members had been treated for MTC and/or pheochromocytoma. The patient had not performed any testing over the last 4 years for personal reasons; she was asymptomatic and 18 weeks pregnant. Blood pressure (125/75mmHg) was normal while heart rate was elevated at 98/min. Her treatment consisted of l-Thyroxine (100μg/day). Routine biological testing, calcemia, thyroid function tests and calcitonin were normal. A 24-hour urinary collection was immediately requested but performed only at 24 weeks of gestation, showing very high concentrations of metanephrines (2519μg/24h, normal values 0–320μg/24h) and normetanephrines (3120μg/24h, 0–390μg/24h) consistent with the diagnosis of pheochromocytoma. A magnetic resonance imaging (MRI) without gadolinium injection confirmed the presence of a right heterogeneous adrenal mass measuring 40×35mm [...]
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Orioli, L., Debiève, F., Donckier, J., Mourad, M., Lois, F., & Maiter, D. (2017). Pheochromocytoma during pregnancy: Case report and review of recent literature. Annales d’Endocrinologie, 78(5), 480-484. https://doi.org/10.1016/j.ando.2017.05.004 (Original work published 2017)