Tumour size over 3 cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group.

Regimbeau, Jean Marc;Fuks, David;Pessaux, Patrick;Bachellier, Philippe;HC-AFC-2009 group;et.al.
(2015) HPB : the official journal of the International Hepato Pancreato Biliary Association — Vol. 17, n° 1, p. 79-86 (2015)

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Authors
  • Regimbeau, Jean Marc
    Author
  • Fuks, David
    Author
  • Pessaux, Patrick
    Author
  • Bachellier, Philippe
    Author
  • Gigot, Jean-FrançoisUCLouvain
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  • HC-AFC-2009 group
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Abstract
(en) INTRODUCTION: As mortality and morbidity after a curative resection remains high, it is essential to identify pre-operative factors associated with an early death after a major resection. METHODS: Between 1998 and 2008, we selected a population of 331 patients having undergone a major hepatectomy including segment I with a lymphadenectomy and a common bile duct resection for a proven hilar cholangiocarcinoma in 21 tertiary centres. The study's objective was to identify pre-operative predictors of early death (<12 months) after a resection. RESULTS: The study cohort consisted of 221 men and 110 women, with a median age of 61 years (range: 24-85). The post-operative mortality and morbidity rates were 8.2% and 61%, respectively. The 1-, 3- and 5-year overall survival rates were 85%, 64% and 53%, respectively. The median tumour size was 23 mm on pathology, ranging from 8 to 40. A tumour size >30 mm [odds ratio (OR) 2.471 (95% confidence interval (CI) 1.136-7.339), P = 0.001] and major post-operative complication [OR 3.369 (95% CI 1.038-10.938), P = 0.004] were independently associated with death <12 months in a multivariate analysis. CONCLUSION: The present analysis of a series of 331 patients with hilar cholangiocarcinoma showed that tumour size >30 mm was independently associated with death <12 months.
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Regimbeau, J. M., Fuks, D., Pessaux, P., Bachellier, P., Chatelain, D., Diouf, M., Raventos, A., Mantion, G., Gigot, J.-F., Chiche, L., Pascal, G., Azoulay, D., Laurent, A., Letoublon, C., Boleslawski, E., Rivoire, M., Mabrut, J.-Y., Adham, M., Le Treut, Y.-P., et al. (2015). Tumour size over 3 cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group. HPB : the official journal of the International Hepato Pancreato Biliary Association, 17(1), 79-86. https://doi.org/10.1111/hpb.12296 (Original work published 2015)