Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age

Gies, Inge;Thomas, Muriel;Tenoutasse, Sylvie;De Waele, Kathleen;De Schepper, Jean;et.al.
(2012) Hormone Research in Paediatrics : from developmental endocrinology to clinical research — Vol. 78, n° 1, p. 24-30 (2012)

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  • Gies, Inge
    Author
  • Thomas, Muriel
    Author
  • Tenoutasse, Sylvie
    Author
  • De Waele, Kathleen
    Author
  • Beckers, DominiqueUCLouvain
    Author
  • Maes, MarcUCLouvain
    Author
  • De Schepper, Jean
    Author
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Abstract
Aim: To study the relationship between insulin sensitivity and growth response in short children born small for gestational age (SGA) treated with growth hormone (GH). Methods: Randomized, open-label, 24-month intervention study in 40 short prepubertal SGA children [age (mean ± SD) 5.3 ± 1.5 years], who either remained untreated (n = 20) or were treated with GH (66 μg/kg/day; n = 20). Changes in fasting glucose, insulin, quantitative insulin sensitivity check index (QUICKI), IGF-1 and leptin after 1 and 2 years were studied. Results: Mean height SDS increased from -3.3 ± 0.7 to -2.3 ± 0.7 after 1 year, and to -1.9 ± 0.7 after 2 years of treatment. QUICKI decreased significantly (p = 0.008) in the first year of GH treatment and stabilized in the second year. Baseline QUICKI was positively associated (r = 0.40; p < 0.05) with the change in height SDS in the first year. Conclusion: Higher insulin sensitivity at the start of GH therapy is associated with greater first-year growth response to GH, and could be a promising parameter in selecting prepubertal short SGA children for GH treatment. However, this finding needs to be confirmed in larger studies. Copyright © 2012 S. Karger AG, Basel.
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Gies, I., Thomas, M., Tenoutasse, S., De Waele, K., Lebrethon, M.-C., Beckers, D., François, I., Maes, M., Rooman, R., De Beaufort, C., Massa, G., & De Schepper, J. (2012). Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age. Hormone Research in Paediatrics : from developmental endocrinology to clinical research, 78(1), 24-30. https://doi.org/10.1159/000339829 (Original work published 2012)