Application of MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement) to Study Variations in Tumor Oxygenation

Jordan, Bénédicte;Magat, Julie;Colliez, Florence;Ozel, Elif;Gallez, Bernard;et.al.
(2013) Advances in Experimental Biology — Vol. 789, p. 281-288 (2013)

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Authors
  • Jordan, Bénédicteorcid-logoUCLouvain
    Author
  • Magat, JulieUCLouvain
    Author
  • Colliez, FlorenceUCLouvain
    Author
  • Ozel, ElifUCLouvain
    Author
  • Fruytier, Anne-CatherineUCLouvain
    Author
  • Marchand, ValérieUCLouvain
    Author
  • Mignion, Lionelorcid-logoUCLouvain
    Author
  • Gallez, Bernardorcid-logoUCLouvain
    Author
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Abstract
The aim of the study was to sensitively monitor changes in tumor oxygen using the MOBILE (mapping of oxygen by imaging lipids relaxation enhancement) technique. This method was applied in mammary tumor mouse models on an 11.7T Bruker MRI system. MOBILE was compared with functional imaging R2*, R1 of water and with pO2 measurements (using EPR oximetry and O2-dependent fluorescence quenching measurements). MOBILE was shown to be capable to monitor changes in oxygenation in tumor tissues.
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Jordan, B., Magat, J., Colliez, F., Ozel, E., Fruytier, A.-C., Marchand, V., Mignion, L., & Gallez, B. (2013). Application of MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement) to Study Variations in Tumor Oxygenation. Advances in Experimental Biology, 789, 281-288. https://doi.org/10.1007/978-1-4614-7411-1_38 (Original work published 2013)