Iron Uptake and Utilization By Mammalian-cells .1. Cellular Uptake of Transferrin and Iron

Octave, Jean-Noël;Schneider, Yves-Jacques;Trouet, André;Crichton, Robert
(1983) Trends in Biochemical Sciences — Vol. 8, n° 6, p. 217-220 (1983)

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Authors
  • Octave, Jean-NoëlUCLouvain
    Author
  • Schneider, Yves-JacquesUCLouvain
    Author
  • Trouet, AndréUCLouvain
    Author
  • Crichton, RobertUCLouvain
    Author
Abstract
The uptake of transferrin-bound iron by cultured mammalian cells involves receptor-mediated endocytosis and internalization of the transferrin-receptor complex, followed by iron release in an intracellular acidic vesicle (which may be the endocytic vesicle itself or a lysosome). The iron is transferred in large part to cytosol ferritin, while the iron-depleted transferrin is recycled back to the plasma membrane and released intact into the extracellular medium. In addition, in some cell types transferrin is also internalized by fluid-phase or adsorptive endocytosis, its iron is released and the protein is degraded in lysosomes.
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Octave, J.-N., Schneider, Y.-J., Trouet, A., & Crichton, R. (1983). Iron Uptake and Utilization By Mammalian-cells .1. Cellular Uptake of Transferrin and Iron. Trends in Biochemical Sciences, 8(6), 217-220. https://doi.org/10.1016/0968-0004(83)90217-7 (Original work published 1983)