Tri- and tetravalent photoactivable cross-linking agents

Welle, Alexandre;Billard, François;Marchand-Brynaert, Jacqueline
(2012) Synthesis : journal of synthetic organic chemistry — Vol. 44, n° 14, p. 2249-2254 (2012)

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  • Welle, AlexandreUCLouvain
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  • Marchand-Brynaert, JacquelineUCLouvain
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Abstract
A modular synthesis of photoactivable cross-linking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Symmetrical and nonsymmetrical trivalent structures were obtained from phloroglucinol and dopamine, respectively. Symmetrical tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride. © Georg Thieme Verlag Stuttgart New York.
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Welle, A., Billard, F., & Marchand-Brynaert, J. (2012). Tri- and tetravalent photoactivable cross-linking agents. Synthesis : journal of synthetic organic chemistry, 44(14), 2249-2254. https://doi.org/10.1055/s-0031-1290444 (Original work published 2012)