In vitro and fully mature in vivo function of human induced pluripotent stem cell-derived beta cells

Fantuzzi, Federica;Chae, Heeyoung;Cai, Ying;Igoillo-Esteve, Mariana;Cnop, Miriam;et.al.
(2019) 55th EASD Annual Meeting of the European Association for the Study of Diabetes — Location: (Spain) Barcelona (16.September.2019)

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Authors
  • Fantuzzi, Federica
    Author
  • Chae, HeeyoungUCLouvain
    Author
  • Cai, Ying
    Author
  • Igoillo-Esteve, Mariana
    Author
  • Gilon, Patrickorcid-logoUCLouvain
    Author
  • Cnop, Miriam
    Author
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Abstract
Background and aims: Pancreatic β-cell failure is central in the pathogenesis of diabetes. In vitro differentiation of human induced pluripotent stem cells (iPSCs) into β-cells represents a novel cell source for diabetes research. Here we differentiated iPSC-β-cells and tested their function in vitro and in vivo in humanized mice [...]
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Fantuzzi, F., Chae, H., Cai, Y., Igoillo-Esteve, M., Demarez, C., Pachera, N., Toivonen, S., Rajaei, B., Marselli, L., Marchetti, P., Eizirik, D. L., Gilon, P., & Cnop, M. (2019). In vitro and fully mature in vivo function of human induced pluripotent stem cell-derived beta cells. Diabetologia : clinical and experimental diabetes and metabolism, 62(Suppl 1), S74. https://hdl.handle.net/2078.5/119076 (Original work published 2019)