Regulation of adipokines by hormones and inflammation in human omental adipocytes
(2007) 43rd EASD Annual Meeting of the European Association for the Study of Diabetes — Location: (Netherlands) Amsterdam (18.September.2007)
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- Authors
Maury, Eléonore 
- Abstract
- Background and Aims: We have identified six adipokines that are oversecreted by omental adipose tissue (OAT) in obesity: 3 chemokines [Growth-Related Oncogen factor (GRO), Regulated upon Activation Normal T cells Expressed and Secreted (RANTES), Macrophage Inflammatory Protein-1ß (MIP-1ß)], 1 interleukin (IL-7), 1 tissue inhibitor of metalloproteinases (TIMP-1) and 1 growth factor (thrombopoietin, TPO). Enhanced expression of these adipokines in adipocytes did correlate with several features of the metabolic syndrome. The aim of the present study was to examine whether the abnormal hormonal milieu and/or the chronic inflammation state that prevail in obesity could contribute to such dysregulation of adipokine production. We thus examined the effect of some hormones (insulin, glucocorticoids and catecholamines) and the proinflammatory cytokine, TNFĮ on these adipokines in omental adipocytes.[...]
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Citations
Maury, E., Ehala-Aleksejev, K., Noel, L., & Brichard, S. (2007). Regulation of adipokines by hormones and inflammation in human omental adipocytes. Diabetologia : clinical and experimental diabetes and metabolism, 50(Suppl 1), S69. https://hdl.handle.net/2078.5/55988 (Original work published 2007)