(en) The predominance of joint and muscle bleeding in people with haemophilia means that the consequences of the disorder are mainly musculoskeletal.1 These consequences impact on physical function of upper and lower limbs which in turn limits an individual's ability to perform daily tasks as well as participate fully in all areas of life. In the past decade, there has been a rapid and unprecedented increase in the available medical treatment options for haemophilia, including extended half‐life clotting factor concentrates, non‐replacement therapies such as Emicizumab and gene therapy.2 These advances are likely to enable people with haemophilia with and without inhibitor the potential to lead a more active lifestyle with enhanced physical function as well as lowering bleeding frequency. The subsequent reduction in bleeding frequency may result in more subtle and less clinically evident early signs of arthropathic change. As a consequence, it is very likely that the measurement of the annual bleeding rate will no longer be a sensitive tool for measuring the effectiveness of treatments. [...]
Lobet, S., Hermans, C., & Stephensen, D. (2020). The emerging clinical and scientific role of the physiotherapist in haemophilia care. Haemophilia (Print), 26(4), 560-562. https://doi.org/10.1111/hae.14096 (Original work published 2020)