Persistence of fetal hemoglobin production after successful transplantation of cord blood stem cells in a patient with sickle cell anemia.

Brichard, Bénédicte;Vermylen, Christiane;Ninane, J.;Cornu, Guy
(1996) The Journal of Pediatrics — Vol. 128, n° 2, p. 241-243 (1996)

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Authors
  • Brichard, BénédicteUCLouvain
    Author
  • Vermylen, ChristianeUCLouvain
    Author
  • Ninane, J.
    Author
  • Cornu, GuyUCLouvain
    Author
Abstract
A girl with sickle cell anemia was treated with cord blood transplantation combined with hematopoietic growth factor. Cord blood cells were collected from a sister with an identical human leukocyte antigen complex who was a carrier of the sickle cell trait (hemoglobin AS). The patient had complete engraftment and no graft-versus-host disease. The persistence of a high level of fetal hemoglobin 6 months after engraftment was noted.
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Brichard, B., Vermylen, C., Ninane, J., & Cornu, G. (1996). Persistence of fetal hemoglobin production after successful transplantation of cord blood stem cells in a patient with sickle cell anemia. The Journal of Pediatrics, 128(2), 241-243. https://doi.org/10.1016/S0022-3476(96)70398-0 (Original work published 1996)