NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
(2021) Journal of Reproductive Immunology — Vol. 148, n° 148, p. 103427 (2021)
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- Abstract
- To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-CoV-2 can enter cells and damage them through its common receptors in the reproductive tissues, and secondly, inflammasome pathway activation is responsible for the damages caused, then the inflammasome inhibitors might be considered as suitable candidates in preventing the pathological effects on the germ cells and reproductive tissues and subsequent fertility.
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Citations
Bazrafkan, M., Hosseini, E., Nazari, M., Andrade Amorim, C., & Sadeghi, M. R. (2021). NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems. Journal of Reproductive Immunology, 148(148), 103427. https://doi.org/10.1016/j.jri.2021.103427 (Original work published 2021)