Crystal-structure and In-vitro Antitumor-activity of Dibutylbis(5-chloro-2-hydroxybenzoato)tin(iv)
(1994) Applied Organometallic Chemistry — Vol. 8, n° 1, p. 19-23 (1994)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- The crystal structure of the title compound, [nBu2Sn(5-Cl-2-OH-C6H3CO2)2], shows that in the monomeric species the six-coordinate Sn atom exists in a skew trapezoidal bipyramidal geometry in which the four 0 donor atoms, derived from two asymmetrically chelating carboxylate ligands, define the basal plane and the n-butyl substituents lie over the weaker Sn-O interactions defining a C-Sn-C angle of 147.6(2)-degrees. An unusual feature of the structure is the presence of both intra- and inter-molecular hydrogen bonding contacts which serve to stabilize the structure. The in vitro antitumour activity of this compound against mammary and colon carcinoma cell lines is also reported.
- Affiliations
Citations
Gielen, M., Boualam, M., Mahieu, B., & Tiekink, ERT. (1994). Crystal-structure and In-vitro Antitumor-activity of Dibutylbis(5-chloro-2-hydroxybenzoato)tin(iv). Applied Organometallic Chemistry, 8(1), 19-23. https://doi.org/10.1002/aoc.590080105 (Original work published 1994)