Fused micro-computed tomography (μCT) and histological images of bone specimens.
(2018) Diagnostic & Interventional Imaging — Vol. 99, n° 7-8, p. 501-505 (2018)
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- Abstract
- OBJECTIVES: To describe a stepwise process to obtain fused images from micro-computed tomography (μCT) and histological images of bone specimens. MATERIAL AND METHODS: Four surgically resected human femoral heads from four patients who had total hip replacement were imaged at a spatial resolution of 12-microns by using μCT. Histological sections of four focal bone lesions including bone cyst in osteoarthritis (n=2) and subchondral bone plate fracture in osteonecrosis (n=2) were prepared and digitized. μCT images were reformatted and adjusted to match the histological images using a landmark-based visual co-registration. Fused μCT and histological images were displayed in a cine-loop video mode with a gradual transition from one image to the other. RESULTS: μCT images of the four focal bone lesions could be successfully fused with the corresponding histological images with a near perfect match of the bone trabeculae. CONCLUSION: We present a stepwise process to obtain fused images from histological and reformatted μCT images of human femoral heads.
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Mourad, C., Laperre, K., Halut, M., Galant, C., Van Cauter, M., & Vande Berg, B. (2018). Fused micro-computed tomography (μCT) and histological images of bone specimens. Diagnostic & Interventional Imaging, 99(7-8), 501-505. https://doi.org/10.1016/j.diii.2018.01.011 (Original work published 2018)