ER Stress Induces Anabolic Resistance in Muscle Cells through PKB-Induced Blockade of mTORC1.
(2011) PLoS One — Vol. 6, n° 6, p. e20993 (2011)
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- Abstract
- Anabolic resistance is the inability to increase protein synthesis in response to an increase in amino acids following a meal. One potential mediator of anabolic resistance is endoplasmic reticulum (ER) stress. The purpose of the present study was to test whether ER stress impairs the response to growth factors and leucine in muscle cells.
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Deldicque, L., Bertrand, L., Patton, A., Francaux, M., & Baar, K. (2011). ER Stress Induces Anabolic Resistance in Muscle Cells through PKB-Induced Blockade of mTORC1. PLoS One, 6(6), e20993. https://doi.org/10.1371/journal.pone.0020993 (Original work published 2011)