Synthesis and Distribution of N-benzyloxycarbonyl-[c-14]-glycine, a Lipophilic Derivative of Glycine
(1995) Journal of Labelled Compounds and Radiopharmaceuticals — Vol. 36, n° 4, p. 397-406 (1995)
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- Abstract
- N-benzyloxycarbonyl[C-14]-glycine, a lipophilic derivative of glycine exhibiting anticonvulsant properties, was prepared in one step from [U-C-14] glycine and benzyl chloroformate in alkali medium. A comparative study of biodistribution was carried on mice between this compound and the parent amino-acid after intravenous administration. Dimethylsulfoxide was used as injection vehicle for N-benzyloxycarbonylglycine. The influence of this injection vehicle was studied comparing glycine injected in a saline solution and glycine co-administered with dimethylsulfoxide. No significant difference was found between these two treatments. Compared to glycine, N-benzyloxycarbonylglycine reached quickly the central nervous system and exhibited an enhanced brain penetration index, 13-fold superior to the parent aminoacid value.
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Lambert, DM., Gallez, B., & Poupaert, J. (1995). Synthesis and Distribution of N-benzyloxycarbonyl-[c-14]-glycine, a Lipophilic Derivative of Glycine. Journal of Labelled Compounds and Radiopharmaceuticals, 36(4), 397-406. https://doi.org/10.1002/jlcr.2580360414 (Original work published 1995)