The artificial ovary: current status and future perspectives
(2016) Future Oncology — Vol. 12, n° 20, p. 2323-2332 (2016)
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- Cryopreservation and transplantation of ovarian tissue has proved to be a promising technique to safeguard fertility in cancer patients. However, with some types of cancer, there is a risk of transmitting malignant cells present in the cryopreserved tissue, so transplantation after disease remission is not advisable. To restore fertility in these patients, some research teams have been developing a transplantable artificial ovary, whose main goal is to mimic the natural organ. It should be composed of a matrix that encapsulates and protects follicles, as well as ovarian cells, which are necessary for follicle survival and development. This article reviews progress made in the creation of a transplantable artificial ovary and discusses future trends for its development.
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Andrade Amorim, C., & Shikanov, A. (2016). The artificial ovary: current status and future perspectives. Future Oncology, 12(20), 2323-2332. https://doi.org/10.2217/fon-2016-0202 (Original work published 2016)