The endothelin ETA receptor antagonist, BQ-123, normalizes the response of SHR aorta to Ca2+ channel activator
(1994) European Journal of Pharmacology — Vol. 252, n° 2, p. R3-R4 (1994)
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- Abstract
- Hypertension is associated with a hypersensitive response to the Ca2+ channel activator, Bay K 8644. We investigated the effect of the endothelin ETA receptor antagonist, BQ-123, on the contractions induced by Bay K 8644 in aorta from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. BQ-123 (1 microM) decreased the sensitivity to Bay K 8644 of aorta of SHR down to that of WKY. This observation is consistent with a role for endothelin in hypertension.
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Morel, N., & Godfraind, T. (1994). The endothelin ETA receptor antagonist, BQ-123, normalizes the response of SHR aorta to Ca2+ channel activator. European Journal of Pharmacology, 252(2), R3-R4. https://doi.org/10.1016/0014-2999(94)90603-3 (Original work published 1994)