PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements
(2005) Genes, Chromosomes & Cancer — Vol. 44, n° 2, p. 218-223 (2005)
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- We present an extensive characterization of 10 B-cell lymphomas with a t(9; 14)(p I 3;q32). The presence of the PAX5/IGH gene rearrangement was demonstrated by fluorescence in situ hybridization (FISH) using a validated probe set, whereas complex karyotypic changes were reassessed by multiplex-FISH (M-FISH). Pathologic and clinical review revealed the presence of this rearrangement in 4 histiocyte-rich, T-cell-rich B-cell lymphomas (HRTR-BCLs) and 2 posttransplantation diffuse large B-cell lymphomas (PTLD-DLBCLs). In contrast to initial observations describing this translocation in lymphoplasmacytic lymphoma (LPL) and LPL-derived large B-cell lymphoma, our data showed a wide morphologic and clinical spectrum associated with the PAX5/IGH rearrangement, pointing to an association between this aberration and a subset of de novo DLBCLs presenting with advanced disease and adverse prognosis. In addition, the recurrent incidence of this rearrangement in both HRTR-BCL (4 cases) and PTLD-DLBCL (2 cases) was previously unrecognized and is intriguing. (c) 2005 Wiley-Liss, Inc.
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Poppe, B., De Paepe, P., Michaux, L., Dastugue, N., Bastard, C., Herens, C., Moreau, E., Cavazzini, F., Yigit, N., Van Limbergen, H., De Paepe, A., Praet, M., De Wolf-Peeters, C., Wlodarska, I., & Speleman, F. (2005). PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements. Genes, Chromosomes & Cancer, 44(2), 218-223. https://doi.org/10.1002/gcc.20214 (Original work published 2005)