Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis

Marot, Astrid;Morelle, Johann;Chouinard, Virginie-Anne;Jadoul, Michel;Demoulin, Nathalie;et.al.
(2011) Acta Clinica Belgica (Multilingual Edition) — Vol. 66, n° 2, p. 134-136 (2011)

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Abstract
Myopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy. Predisposing factors include comorbidities and the concomitant use of cytochrome P-450 (CYP) 3A4 inhibitors. We report a case of severe simvastatin-induced rhabdomyolysis triggered by the addition of amiodarone to previously well-tolerated chronic statin therapy. Physicians should be aware of the risk of this potentially severe drug interaction. The dose of simvastatin should be reduced (to 20 mg daily) when concomitant treatment with amiodarone is required, or preference should be given to pravastatin, rosuvastatin or fluvastatin, which are not metabolised by the CYP 3A4.
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Marot, A., Morelle, J., Chouinard, V.-A., Jadoul, M., Lambert, M., & Demoulin, N. (2011). Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis. Acta Clinica Belgica (Multilingual Edition), 66(2), 134-136. https://hdl.handle.net/2078.5/208255 (Original work published 2011)