Effect of HLA matching in simultaneous pancreas-kidney transplantation.
(2005) Transplantation Proceedings — Vol. 37, n° 6, p. 2846-2847 (2005)
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- Simultaneous pancreas-kidney (SPK) transplantation has become the therapy of choice for type 1 diabetic patients with end-stage renal disease. The current analysis examined the impact of HLA matching on graft outcome following SPK transplantation. The study population was obtained from patients enrolled in the Euro-SPK 001 study. PATIENTS AND METHODS: The effect of HLA matching on graft function and survival was assessed in 180 SPK recipients in whom complete donor-recipient HLA data were available. A group of 45 patients with 0 to 3 HLA mismatches (MM) was compared to 135 patients with 4 to 6 MM. RESULTS: There were no differences in 3-year kidney, pancreas, or patient survival rates between the 0 to 3 and 4 to 6 MM groups. Biological parameters of kidney and pancreas graft function were similar in both groups. Significantly more patients with 0 to 3 MM (66%) were rejection free at 3 years than those with 4 to 6 MM (41%; P = .003). The relative risk of acute rejection was 2.6 times higher among patients with 4 to 6 MM than among those with 0 to 3 MM. In conclusion, there was no evidence that HLA matching was associated with improved kidney or pancreas survival. However, a higher rate of acute rejection was observed with poor HLA matches, which may impact long-term survival.
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Malaise, J., Berney, T., Morel, P., Toso, C., Demuylder-Mischler, S., Majno, P., Bühler, L., Mentha, G., VAN OPHEM, D., & Squifflet, J.-P. (2005). Effect of HLA matching in simultaneous pancreas-kidney transplantation. Transplantation Proceedings, 37(6), 2846-2847. https://doi.org/10.1016/j.transproceed.2005.05.023 (Original work published 2005)