ZO-2 enriched tight junction-like structures at sites of platelet-platelet contact
(2022) The ISTH 2022 Congress (International Society on Thrombosis and Haemostasis) — Location: Londres, Angleterre (9.July.2022)
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- INTRODUCTION Platelets express junction proteins that are known to regulate cell-cell adhesion, barrier formation and communication in tissue forming cells. Previous research has shown that the gap junction proteins expressed by platelets regulate platelet activation in an αIIbβ3-dependent manner.1 Also, platelet activation processes are negatively regulated by endothelial cell-selective adhesion molecule (ESAM)2 and junctional adhesion molecule A (JAM-A)3, proteins that are part of the tight junctions (TJ) of endothelial cells. However, the role of zonula occludens 2 (ZO-2) -an intracellular component of the endothelial TJs- in the formation of inter-platelet contacts has not yet been described.
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Nagy, M., Bender, M., Poulter, N., Sickmann, A., Stephenne, X., Brouns, S., Koenen R, Ten Cate, H., Heemskerk, J., & Baaten, C. (2022). ZO-2 enriched tight junction-like structures at sites of platelet-platelet contact. The ISTH 2022 Congress (International Society on Thrombosis and Haemostasis), Londres, Angleterre. https://hdl.handle.net/2078.5/103356