Making β cells from adult cells within the pancreas

Lysy, Philippe;Weir, Gordon C;Bonner-Weir, Susan
(2013) Current Diabetes Reports —

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Authors
  • Lysy, PhilippeUCLouvain
    Author
  • Weir, Gordon CJoslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School
    Author
  • Bonner-Weir, SusanJoslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School
    Author
Abstract
Cell therapy is currently considered as a potential therapeutic alternative to traditional treatments of diabetes. Islet and whole pancreas transplantations provided the proof-of-concept of glucose homeostasis restoration after replenishment of the deficiency of β cells responsible for the disease. Current limitations of these procedures have led to the search for strategies targeting replication of pre-existing β cells or transdifferentiation of progenitors and adult cells. These investigations revealed an unexpected plasticity towards β cells of adult cells residing in pancreatic epithelium (eg, acinar, duct, and α cells). Here we discuss recent developments in β-cell replication and β-cell transdifferentiation of adult epithelial pancreatic cells, with an emphasis on techniques with a potential for clinical translation.
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Lysy, P., Weir, G. C., & Bonner-Weir, S. (2013). Making β cells from adult cells within the pancreas. Current Diabetes Reports. https://doi.org/10.1007/s11892-013-0400-1