[Radiolysis and Radiosterilization of Drugs]
(1993) STUDY CONGRESS ON RADIATION CHEMISTRY ( JECR-92 ) — Location: AIX EN PROVENCE(France) (17.May.1992)
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- Abstract
- Can the absence of increased toxicological danger in irradiated foods be applied with confidence to drugs ? The World Health Organization stated that up to 10 kGy there is no toxicological hazard. However, even if the irradiated drugs meet official standards, it would have to be established that any traces of radiolysis product formed are not toxic. All the tests from PHARMACOPEIA are not appropriate to detect the radiolysis and new physicochemical tests have to be used. Chromatographic detection of the radiosterilization of antibiotics may be advantageously used when the pharmaceuticals are not radio-resistant. The main obstacle to pratical application is the low sensitivity of the detectors in liquid-liquid chromatography, a re-irradiation of the suspected samples will be necessary after preliminary chromatographic studies.
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Zeegers, F., Crucq, AS., Gibella, M., & Tilquin, B. (1993). [Radiolysis and Radiosterilization of Drugs]. Journal de Chimie Physique, 90(4), 1029-1040. https://hdl.handle.net/2078.5/88148 (Original work published 1993)