Les critères diagnostiques du syndrome de Lynch
(2013) Louvain médical — Vol. 132, n° 9, p. 636-642 (2013)
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- (en) The Lynch syndrome, which is the most common colon cancer predisposition syndrome, has been known for a long time. However, misconceptions about this disease remain widespread. Two main reasons account for this paradoxical situation: 1 - The Lynch syndrome was described long before the discovery of the MSI-H tumors' peculiar biology; 2-The rationale underlying the Amsterdam criteria led to presenting the Lynch syndrome in a distorted way, without addressing the disease's features for their own sake, but by explaining that the Lynch syndrome is not a dominant familial polyposis. Aim of this brief review is to settle right some of the most widespread misconceptions about the Lynch syndrome and to provide some simple rules that should enable an easy diagnosis of the disease
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Citations
Janin, N. (2013). Les critères diagnostiques du syndrome de Lynch. Louvain médical, 132(9), 636-642. https://hdl.handle.net/2078.5/36159 (Original work published 2013)