Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam

Buol, Xavier;Caro Garrido, Camila;Robeyns, Koen;Tumanov, Nikolay;Leyssens, Tom;et.al.
(2020) Crystal Growth & Design — Vol. 20, n° 12, p. 7979-7988 (2020)

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Abstract
In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98–99%) was obtained with a process that can run for multiple cycles.
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Buol, X., Caro Garrido, C., Robeyns, K., Tumanov, N., Collard, L., Wouters, J., & Leyssens, T. (2020). Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam. Crystal Growth & Design, 20(12), 7979-7988. https://doi.org/10.1021/acs.cgd.0c01236 (Original work published 2020)