(fr) Despite significant advancements in cancer therapy, treating cancer patients remains challenging mainly due to several therapy evasion mechanisms, which are still not well characterized, and severe side effects that limit the usage and clinical benefit of anti-cancer therapies. Since the implementation of immunotherapy, cancer research has been focused on understanding the complex heterogeneity of the tumor microenvironment (TME) to turn non-responsive—or “cold” tumors—into more treatable and responsive diseases—then defined as “hot”. [...]
Biagioni, A., Petroni, G., Corbet, C., & Andreucci, E. (2024). Editorial: Turning cold tumors hot: insights into molecular mechanisms and clinical applications of immunogenic cell death. Frontiers in Cell and Developmental Biology, 12(1), 1496001 [1-2]. https://doi.org/10.3389/fcell.2024.1496001 (Original work published 2024)