Mutagenic potency of heterocyclic amines towards Salmonella typhimurium; possible causes of variability in the results observed.
(1992) Mutation Research — Vol. 280, n° 2, p. 103-107 (1992)
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- Abstract
- The potent food mutagens and carcinogens 2-amino-3-methylimidazol[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MEIQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) are probably the most active bacterial mutagens so far discovered. Important discrepancies were found, however, in the specific mutagenicities published for these compounds. This paper analyzes a number of experimental factors that could explain these differences: purity of the compounds, stability under the experimental conditions employed, solvents used, bacterial toxicity, testing procedure, amount and age of the S9 fraction, dose-effect relationships, day-to-day variability, origin of the compounds investigated or of the bacterial strain and age of the strain culture used. None of these factors was found to play a critical role, when the other experimental conditions were strictly standardized. The in-house testing procedure used probably explains the interlaboratory variations observed.
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Brams, A., & De Meester, C. (1992). Mutagenic potency of heterocyclic amines towards Salmonella typhimurium; possible causes of variability in the results observed. Mutation Research, 280(2), 103-107. https://hdl.handle.net/2078.5/131997 (Original work published 1992)