Pre- and postnatal low protein diet affect pancreatic islet blood flow and insulin release in adult rats.
(1996) Endocrinology — Vol. 137, n° 9, p. 3797-3801 (1996)
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- Abstract
- The pancreatic islet blood flow and insulin secretion of adult rats submitted to an isocaloric low protein diet (8% vs. 20%) during pre- and postnatal life were investigated by the nonradioactive microsphere technique. In the basal state, female rats chronically exposed to a low protein diet (LP) displayed a specific marked decrease in islet blood flow (10 +/- 2 vs. 29 +/- 5 microliters/min.g pancreas; P < 0.01) and overall pancreatic blood flow (P < 0.01). The plasma insulin level, however, was not affected. During a glucose challenge, the control animals enhanced their islet blood flow 2.3-fold, whereas the LP group reached control values with a 6-fold increase. Plasma insulin levels rose similarly in the control and LP animals. A third group of animals designated the recuperation group, exposed to a low protein diet only in utero, displayed islet blood flow comparable to control values, but increased basal plasma insulin (2.0 +/- 0.3 vs. 1.2 +/- 0.1 ng/ml; P < 0.05). These data are consistent with the possibility of dissociation of islet blood flow and insulin release under basal conditions, which may not be the case after a glucose challenge. Furthermore, the low blood flow values in the LP group may reflect an adaptive physiological response, an impaired pancreatic vasculogenesis, or a dysfunction of endothelial cells.
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Iglésias-Barreira, V., Ahn, M.-T., Reusens, B., Dahri, S., Hoet, J. J., & Remacle, C. (1996). Pre- and postnatal low protein diet affect pancreatic islet blood flow and insulin release in adult rats. Endocrinology, 137(9), 3797-3801. https://doi.org/10.1210/en.137.9.3797 (Original work published 1996)