The Ctns(-/-) mouse model generated on C57BL/6 background is not suitable for clarifying the pathogenesis of male infertility in cystinosis. The etiology of nonobstructive azoospermia in these patients remains unclear.
Besouw, M. T. P., van Pelt, A. M. M., Gaide Chevronnay, H. P., Courtoy, P., Pastore, A., Goossens, E., Devuyst, O., Antignac, C., & Levtchenko, E. N. (2012). Studying nonobstructive azoospermia in cystinosis: histologic examination of testes and epididymis and sperm analysis in a Ctns⁻/⁻ mouse model. Fertility and Sterility, 98(1), 162-165. https://doi.org/10.1016/j.fertnstert.2012.03.050 (Original work published 2012)