Synthesis and pH-dependent micellization of diblock copolymer mixtures
(2009) Journal of Colloid and Interface Science — Vol. 329, n° 2, p. 235-243 (2009)
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- This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(epsilon-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL34-b-PEO114 and PCL32-b-P2VP(52) diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks-thus on the composition, shape, size and surface properties of the micelles-was Studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test. (C) 2008 Elsevier Inc. All rights reserved.
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Van Butsele, K., Sibret, P., Fustin, C.-A., Gohy, J.-F., Passirani, C., Benoit, J.-P., Jérome, R., & Jérôme, C. (2009). Synthesis and pH-dependent micellization of diblock copolymer mixtures. Journal of Colloid and Interface Science, 329(2), 235-243. https://doi.org/10.1016/j.jcis.2008.09.080 (Original work published 2009)