Real-world Glycemic and Person-Reported Outcomes after Tandem Control-IQ initiation in Children with Type 1 Diabetes.
(2025) Journal of Clinical Endocrinology and Metabolism — Vol. 110, n° 12, p. 3331-3341 (2025)
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- Authors
De Meulemeester, Jolien 
Valgaerts, Laura Gillard, Pieter
- Abstract
- This multicenter prospective observational cohort study assessed real-world changes in glycemic and person-reported outcomes one-year after Control-IQ initiation in children and adolescents with type 1 diabetes. Between October 2021 and December 2022, all children 6-18 years who started Control-IQ at 13 Belgian centers were consecutively recruited. Data were collected at start of Control-IQ and after 4, 8 and 12 months. Person-reported outcomes were evaluated through questionnaires (Diabetes Quality of Life for Youth [DQOLY], Hypoglycemia Fear Survey [HFS], HAPPI-D). Data are reported as mean ± SD or least-squares mean (95% CI). A total of 114 children were included, with a mean age of 12.0 ± 3.2 years and of whom 61.4% were girls. Time in range (3.9-10.0 mmol/L) increased from start (51.6% [47.6-55.5]) to 12 months (64.4% [61.2-67.5]) (p<0.001). After 12 months, HbA1c decreased from 62 mmol/mol (60-65) (7.8% [7.6-8.1]) to 54 mmol/mol (52-56) (7.1% [6.9-7.3]) and time <3.9 mmol/L from 3.9% (3.1-4.8) to 2.7% (1.9-3.5) (all p<0.001). Children scored better on DQOLY satisfaction (70.4 [67.8-73.0] vs 74.0 points [71.3-76.6]) and DQOLY impact (54.6 [50.9-58.3] vs 51.3 points [47.4-55.1]), and parents on HAPPI-D (22.5 [21.1-23.9] vs 19.6 points [18.2-21.0]) and HFS worry (25.0 [21.6-28.4] vs 20.3 points [17.0-23.5] (all p<0.001). Children missed fewer days of school (287 vs 30 days/100 person-years, p=0.001) and parents missed less days of work (247 vs 47 days/100 person-years, p<0.001). One-year use of Control-IQ was associated with improved glycemic management, more diabetes-related quality of life and fewer school/work absences.
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Citations
De Meulemeester, J., Valgaerts, L., Massa, G., Gies, I., Depoorter, S., Vanaken, S., Chivu, O., den Brinker, M., Mouraux, T., Vanloocke, M., Lebrethon, M.-C., Messaaoui, A., Lysy, P., Dooms, L., Mathieu, C., Casteels, K., & Gillard, P. (2025). Real-world Glycemic and Person-Reported Outcomes after Tandem Control-IQ initiation in Children with Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, 110(12), 3331-3341. https://doi.org/10.1210/clinem/dgaf265 (Original work published 2025)