Transdermal permeation of neutral molecules by skin electroporation

Vanbever, Rita;Leroy, Marie-Ange;Préat, Véronique
(1998) Journal of Controlled Release — Vol. 54, n° 3, p. 243-250 (1998)

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  • Vanbever, Ritaorcid-logoUCLouvain
    Author
  • Leroy, Marie-Ange
    Author
  • Préat, VéroniqueUCLouvain
    Author
Abstract
Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold. The elevated flux results from the persistent increase in skin permeability following electroporation, rather than from electro-osmosis during pulsing. Control on transport was achieved by controlling the electrical parameters of the pulse, i.e. the pulse voltage, time constant and number.
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Vanbever, R., Leroy, M.-A., & Préat, V. (1998). Transdermal permeation of neutral molecules by skin electroporation. Journal of Controlled Release, 54(3), 243-250. https://doi.org/10.1016/S0168-3659(97)00146-6 (Original work published 1998)