Cascade of immunologic adverse events related to pembrolizumab treatment

Dhenin, Arnaud;Samartzi, Vassiliki;Lejeune, Sarah;Seront, Emmanuel
(2019) BMJ Case Reports — Vol. 12, n° 6, p. e229149 (2019)

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Authors
  • Dhenin, ArnaudDepartment of Medical Oncology, Hopital de Jolimont, Haine-Saint-Paul, Belgium
    Author
  • Samartzi, VassilikiDepartment of Gynecology, Hopital de Jolimont, Haine-Saint-Paul, Belgium
    Author
  • Lejeune, SarahDepartment of Medical Oncology, Hopital de Jolimont, Haine-Saint-Paul, Belgium
    Author
  • Author
Abstract
Immune checkpoint inhibitors, such as pembrolizumab, have significantly improved cancer patient outcome. Toxicities are usually moderate and manageable. However, some adverse events, if not early recognised, could be life-threatening. We report a patient with non-small cell lung cancer who received treatment with pembrolizumab and developed multiple immune-related adverse events both during and after completing treatment, including rash, pericarditis, colitis and myasthenia gravis.
Affiliations
  • Hopital de Jolimont, Haine-Saint-Paul, BelgiumDepartment of Medical Oncology
  • Hopital de Jolimont, Haine-Saint-Paul, BelgiumDepartment of Gynecology

Citations

Dhenin, A., Samartzi, V., Lejeune, S., & Seront, E. (2019). Cascade of immunologic adverse events related to pembrolizumab treatment. BMJ Case Reports, 12(6), e229149. https://doi.org/10.1136/bcr-2018-229149 (Original work published 2019)