Evolution of the carboxylate Jen transporters in fungi

Lodi, Tiziana;Diffels, Julie;Goffeau, André;Baret, Philippe
(2007) FEMS Yeast Research — Vol. 7, n° 5, p. 646-656 (2007)

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  • Lodi, Tiziana
    Author
  • Diffels, JulieUCLouvain
    Author
  • Goffeau, AndréUCLouvain
    Author
  • Baret, PhilippeUCLouvain
    Author
Abstract
Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemiascomycetes yeasts and Euascomycetes fungi. It is concluded that a precursor form of Jen1p, named here preJen1p, arose by the duplication of an ancestral Jen2p, during the speciation of Yarrowia lipolytica, which was transferred into a new syntenic context. The Jen1p transporters differentiated from preJen1p in Kluyveromyces lactis, before the Whole Genome Duplication (WGD), and are conserved as a single copy in the Saccharomyces species. In contrast, the ancestral Jen2p was definitively lost just prior to the WGD and is absent in Saccharomyces.
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Lodi, T., Diffels, J., Goffeau, A., & Baret, P. (2007). Evolution of the carboxylate Jen transporters in fungi. FEMS Yeast Research, 7(5), 646-656. https://doi.org/10.1111/j.1567-1364.2007.00245.x (Original work published 2007)