Quality assurance for PET gas production using the cyclone 3D oxygen-15 generator
(1999) 7th International Workshop on Targetry and Target Chemistry — Location: HEIDELBERG(Germany) (8.June.1997)
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- Abstract
- The production and quality control analysis of short-lived (t(1/2)=2.03 min) oxygen-15 labelled gases ([O-15]O-2, [O-15]CO, and [O-15]CO2) from a Cyclone 3D accelerator for positron emission tomography (PET) in human subjects has been established and evaluated on a routine basis use at the MRC Cyclotron Unit and are here described. Contaminant levels have been identified and measured by radio-gas chromatography. The maximum levels allowed, measured as a percentage of total delivered activity (v/v), are 3.7% for total nitrogen oxides and 1% for [O-15]CO in [O-15]CO2 and [O-15]CO2 in [O-15]CO. By adjunction of a cryogenic or molecular sieve trap, radiopharmaceutical gases are routinely produced well within these specifications. (C) 1999 Elsevier Science Ltd. All rights reserved.
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Citations
Mackay, D., Steel, C., Poole, K., McKnight, S., Schmitz, F., Ghyoot, M., Verbruggen, R., Vamecq, F., & Jongen, Y. (1999). Quality assurance for PET gas production using the cyclone 3D oxygen-15 generator. Applied Radiation and Isotopes, 51(4), 403-409. https://doi.org/10.1016/S0969-8043(99)00063-9 (Original work published 1999)