Diagnosis of fatty liver in children should occur in parallel to investigation for other causes of liver disease.

European Society for Paediatric Gastroenterology Hepatology (ESPGHAN);European Association for the Study of the Liver (EASL);Stephenne, Xavier
(2023) The lancet. Gastroenterology & hepatology — Vol. 8, n° 7, p. 598-600 (2023)

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Authors
  • European Society for Paediatric Gastroenterology Hepatology (ESPGHAN)
    Collaborator
  • European Association for the Study of the Liver (EASL)
    Collaborator
  • Stephenne, XavierUCLouvain
    Author
Abstract
Fatty liver is the most common chronic liver disease in European children. Historically, non-alcoholic fatty liver disease (NAFLD) evolved as a diagnosis of exclusion, in which the presence of hepatic steatosis (with or without inflammation and fibrosis) in the absence of an alternative cause (particularly alcohol) led to the diagnosis of NAFLD. Hepatic steatosis has long been recognised as a manifestation of a wide array of conditions, ranging from viral hepatitis, autoimmune liver disease, Wilson's disease, α1-antitrypsin deficiency, and rarer metabolic disorders. Hepatic steatosis is associated with extra-hepatic conditions such as coeliac disease, cystic fibrosis, malnutrition, systemic diseases, various drugs, and parenteral nutrition. Therefore, to make a diagnosis of NAFLD, these conditions must first all be excluded.
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Stephenne, X. (2023). Diagnosis of fatty liver in children should occur in parallel to investigation for other causes of liver disease. The lancet. Gastroenterology & hepatology, 8(7), 598-600. https://doi.org/10.1016/S2468-1253(23)00100-0 (Original work published 2023)