Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU.

Blet, Alice;de Roquetaillade, Charles;Hartmann, Oliver;Struck, Joachim;Castanares Zapatero, Diego;et.al.
(2020) Critical Care — Vol. 24, n° 1, p. 69 [1-6] (2020)

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Authors
  • Blet, Alice
    Author
  • de Roquetaillade, Charles
    Author
  • Hartmann, Oliver
    Author
  • Struck, Joachim
    Author
  • Laterre, Pierre-FrançoisUCLouvain
    Collaborator
  • Berghe, CarolineUCLouvain
    Collaborator
  • Dujardin, Marie-FranceUCLouvain
    Collaborator
  • Renard, SuzanneUCLouvain
    Collaborator
  • Wittebole, XavierUCLouvain
    Collaborator
  • Collienne, ChristineUCLouvain
    Collaborator
  • Castanares Zapatero, Diegoorcid-logoUCLouvain
    Collaborator
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Abstract
To the editor: Sepsis mortality decreased over the last decades, although it remains dramatically high [1]. The implementation of guidelines such as the Surviving Sepsis Campaign (SSC) contributed to these progresses. SSC recommends to guide resuscitation on normalization of lactate levels [2]. Guiding resuscitation on lactate reduction is highly debated [3]. Anyway, normalization of lactate is associated with improved outcome [4]. We have recently shown that plasma levels of bio-adrenomedullin (bio-ADM), a peptide regulating vascular integrity and endothelial function, were associated with patient outcome during sepsis [5]. Interestingly, we observed that patients with elevated bio-ADM levels at admission and with low bio-ADM levels 2 days later had similar outcome to patients with persistently low bio-ADM levels. We therefore aimed to evaluate the added value of bio-ADM to lactate measurement in the AdrenOSS-1 cohort.[...]
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Blet, A., de Roquetaillade, C., Hartmann, O., Struck, J., Mebazaa, A., & Chousterman, B. G. (2020). Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU. Critical Care, 24(1), 69 [1-6]. https://doi.org/10.1186/s13054-020-2794-x (Original work published 2020)