Hyaluronic acid-conjugates for the local chemo-immunomodulation of glioblastoma
(2025)
Files
THESIS.pdf
Embargo from 2026-10-03 - Adobe PDF
- 6.81 MB
Details
- Authors
- Supervisors
- Abstract
- Glioblastoma is the most common and aggressive form of brain cancer, and it remains a major unmet medical need. Localized drug delivery strategies offer promising alternatives to systemic treatments by addressing their inherent limitations. This PhD thesis focuses on developing two localized therapeutic approaches for unresected and resected glioblastoma using hyaluronic acid-drug conjugates. These conjugates have the potential not only to selectively kill glioblastoma cells but also to modulate the tumor microenvironment. In the first part, we explored intra-tumoral treatment of unresected glioblastoma through the repurposing of two chemotherapeutics, selected for both their cytotoxic and immunomodulatory properties, with the aim of reshaping the tumor microenvironment. In the second part, we investigated the treatment of resected glioblastoma using a hemostatic paste loaded with hyaluronic acid-doxorubicin conjugates, designed to eradicate glioblastoma stem cells. Overall, our findings emonstrate the potential of these localized strategies to enhance therapeutic outcomes in glioblastoma.
- Affiliations
UCLouvain SSS/LDRI - Louvain Drug Research Institute
Citations
Rodella, G. (2025). Hyaluronic acid-conjugates for the local chemo-immunomodulation of glioblastoma. https://hdl.handle.net/2078.5/259448