Arid5a: A Missing Link between EMT and Tumoral Immune Resistance.
(2021) Cancer immunology research — Vol. 9, n° 8, p. 854 (2021)
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- Abstract
- Epithelial-to-mesenchymal transition (EMT) endows tumor cells with the ability to invade and migrate, and to suppress antitumor immunity. In this issue, Parajuli and colleagues report that EMT tumors often express the RNA-binding protein AT-rich interactive domain 5a (Arid5a), which they find stabilizes the mRNAs encoding indoleamine 2,3 dioxygenase (IDO1) and CCL2. As a new link between EMT and tumoral immune resistance, Arid5a represents a therapeutic target of interest.
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Citations
Van den Eynde, B. (2021). Arid5a: A Missing Link between EMT and Tumoral Immune Resistance. Cancer immunology research, 9(8), 854. https://doi.org/10.1158/2326-6066.CIR-21-0432 (Original work published 2021)