Antiviral drug susceptibility of human herpesvirus 8
(1997) Antimicrobial Agents and Chemotherapy — Vol. 41, n° 12, p. 2754-2756 (1997)
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- Abstract
- We studied the susceptibility of human herpesvirus 8 (HHV-8) to a number of antiherpesvirus agents. The acyclic nucleoside phosphonate (ANP) analogs cidofovir and HPMPA [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine] effected potent inhibition of HHV-8 DNA synthesis, with 50% effective concentrations (EC50) of 6.3 and 0.6 mu M, respectively. Adefovir, an ANP with both antiretrovirus and antiherpesvirus activity, blocked HHV-8 DNA replication at a fourfold-lower concentration than did foscarnet (EC50 of 39 and 177 mu M, respectively). The most potent inhibitory effect was obtained with the N-7-substituted nucleoside analog S2242 (EC50, 0.11 mu M). The nucleoside analogs acyclovir, penciclovir, H2G {(R)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine}, and brivudine had weak to moderate effects (EC50 of greater than or equal to 75, 43, 42, and 24 mu M, respectively, and EC90 of greater than or equal to 75 mu M), whereas ganciclovir elicited pronounced anti-HHV-8 activity (EC50, 8.9 mu M).
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Neyts, J., & De Clercq, E. (1997). Antiviral drug susceptibility of human herpesvirus 8. Antimicrobial Agents and Chemotherapy, 41(12), 2754-2756. https://hdl.handle.net/2078.5/82429 (Original work published 1997)