Based on their response to sustained heat, thermonociceptors can be categorized as slowly- or rapidly-adapting. The recording of event-related brain potentials to a transient heat stimulus (e.g. brief infrared laser stimulation of the skin) is used extensively to study nociception in humans, and to diagnose neuropathic pain. However, these responses are exclusively related to the activation of rapidly-adapting thermonociceptors. Here, we propose a novel method to record, in humans, cortical activity related to the activation of slowly-adapting thermonociceptors using an ultra-slow periodic heat stimulation to elicit a steady-state evoked brain potential (SS-EP).
Colon, E., & Mouraux, A. (2015). Ultra-slow steady-state evoked potentials to explore the cortical responses to the activation of slowly-adapting heat nociceptors. The 9th congress of European Pain Federation EFIC, Vienna, Austria. https://hdl.handle.net/2078.5/52071