Localization of a Band 3-related protein in the mitochondria-rich cells of amphibian skin epithelium.
(1993) Biology of the Cell — Vol. 78, n° 3, p. 217-221 (1993)
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- Abstract
- Based on immunoblotting procedure, the isolated epithelium of amphibian skin was found to contain a 180 kDa protein which cross-reacts with a polyclonal antiserum raised against human erythrocyte Band 3. Immunoperoxidase and immunofluorescence staining techniques indicated that the Band 3-related protein was localized in the mitochondria-rich cells (MRC) of this epithelium, with characteristic apical labelling pattern. Our findings show that the putative apical anion exchanger of the MRC is immunologically related to the band 3 multigenic family, which catalyzes Cl(-)-HCO3- transmembranous exchange. It thus suggests a molecular basis for the role played by these cells in the transepithelial Cl- pathway and acid-base regulation.
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Devuyst, O., Denef, J.-F., Rott, R., Crabbé, J., & Katz, U. (1993). Localization of a Band 3-related protein in the mitochondria-rich cells of amphibian skin epithelium. Biology of the Cell, 78(3), 217-221. https://doi.org/10.1016/0248-4900(93)90132-X (Original work published 1993)