Focal status epilepticus may trigger relapse of primary angiitis of the CNS.
(2022) Epileptic Disorders — Vol. 24, n° 1, p. 203-207 (2022)
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- Authors
Duprez, Thierry 
- Abstract
- The role of neuroinflammation in epileptogenesis is extensively investigated, but short-term effects of seizures on established CNS pathologies are less studied and less predictable. We describe the case of a woman with previous recurrent episodes of focal cerebral haemorrhage of unknown cause who developed a pseudo-tumoural oedema triggered by provoked focal status epilepticus. A brain biopsy revealed that the underlying condition was primary angiitis of the CNS. Ictal-induced blood-brain barrier dysfunction allows the entry of water and inflammatory molecules that, in the context of CNS inflammatory diseases, may trigger a self-reinforcing process. Caution should be observed when tapering antiepileptic drugs in patients with such conditions.
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Citations
Guilmot, A., Slootjes, S. M., Duprez, T., Lelotte, J., Lammens, M., Peeters, A., & Ferrao Santos, S. (2022). Focal status epilepticus may trigger relapse of primary angiitis of the CNS. Epileptic Disorders, 24(1), 203-207. https://doi.org/10.1684/epd.2021.1381 (Original work published 2022)